In my current research, I am dedicated to generating and analyzing extensive sequencing datasets which are obtained through sequencing of DNA and proteins derived from Lake Zurich microbiomes. The primary objective of my study is to explore the functional characteristics of elusive, yet uncultured bacteria, during lake blooming events. I aim to develop an integrative multi-omics workflow, designed to correlate the genomic potential of these bacteria with their physiological attributes over varying temporal dimensions. This endeavor involves generating environmentally-derived high-quality genomes through the usage of advanced hybrid metagenomics approaches. My goal is to construct sample and species-specific proteomics databases to associate distinct bacteria with their respective in situ functionalities.